Calcium channel blockers (versus unexposed)

Very low Apgar score (< 5) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13875
R54258		 Darcie - Isradipine, 2004 Apgar score (first minute) < 4 late pregnancy prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 1.85 [0.08;41.05] C 2/39   0/14 2 39
ref
Total 1 studies 1.85 [0.08;41.05] 2 39
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Darcie - Isradipine, 2004Darcie - Isradipine, 2004 1.85[0.08; 41.05]2390%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.85[0.08; 41.05]239 -NADarcie - Isradipine, 2004 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.85[0.08; 41.05]239 -NADarcie - Isradipine, 2004 1 Tags Adjustment   - No  - No 1.85[0.08; 41.05]239 -NADarcie - Isradipine, 2004 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.85[0.08; 41.05]239 -NADarcie - Isradipine, 2004 1 All studiesAll studies 1.85[0.08; 41.05]239 -NADarcie - Isradipine, 2004 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.85[0.08; 41.05]239 -NADarcie - Isradipine, 2004 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Firoz (Nifedipine) (Apgar score <4 at 1 min ( ...Firoz (Nifedipine) (Apgar score <4 at 1 min (versus Labetalol iv)) Out of scale0.47[0.05; 4.60]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT1 metaPregmetaPreg 1.85[0.08; 41.05]NaN%39----Darcie - Isradipine, 2004 10.510.01.0