Calcium channel blockers (versus unexposed)

Neonatal hypoglycemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13875
R54262		 Darcie - Isradipine, 2004 Newborns with hypoglycemia (blood glycemia less than 40 mg/dL) late pregnancy prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified 4.00 [1.06;15.08] C 24/39   4/14 28 39
ref
Total 1 studies 4.00 [1.06;15.08] 28 39
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Darcie - Isradipine, 2004Darcie - Isradipine, 2004 4.00[1.06; 15.08]28390%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.00[1.06; 15.08]2839 -NADarcie - Isradipine, 2004 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 4.00[1.06; 15.08]2839 -NADarcie - Isradipine, 2004 1 Tags Adjustment   - No  - No 4.00[1.06; 15.08]2839 -NADarcie - Isradipine, 2004 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 4.00[1.06; 15.08]2839 -NADarcie - Isradipine, 2004 1 All studiesAll studies 4.00[1.06; 15.08]2839 -NADarcie - Isradipine, 2004 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 4.00[1.06; 15.08]2839 -NADarcie - Isradipine, 2004 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Abalos (Neonatal hypoglycaemia (RCT versus no ...Abalos (Neonatal hypoglycaemia (RCT versus no antihypertensive drugs/placebo)) 0.69[0.39; 1.21]NA-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT1 metaPregmetaPreg 4.00[1.06; 15.08]NaN%39----Darcie - Isradipine, 2004 10.510.01.0