Calcium channel blockers (versus unexposed)

Language disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14020
R55119		 Bortolus - Nifedipine, 2000 Language - Parental questionnaire in good agreement with to the Griffiths Mental Developmental Scale - At 18 months 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 1.27 [0.41;3.98] C 9/94   5/65 14 94
ref
Total 1 studies 1.27 [0.41;3.98] 14 94
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bortolus - Nifedipine, 2000Bortolus - Nifedipine, 2000 1.27[0.41; 3.98]14940%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 1.27[0.41; 3.98]1494 -NABortolus - Nifedipine, 2000 1 Type of controls unexposed, sickunexposed, sick 1.27[0.41; 3.98]1494 -NABortolus - Nifedipine, 2000 1 Tags Adjustment   - Randomisation  - Randomisation 1.27[0.41; 3.98]1494 -NABortolus - Nifedipine, 2000 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.27[0.41; 3.98]1494 -NABortolus - Nifedipine, 2000 1 All studiesAll studies 1.27[0.41; 3.98]1494 -NABortolus - Nifedipine, 2000 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.27[0.41; 3.98]1494 -NABortolus - Nifedipine, 2000 10.510.01.0