Calcium channel blockers (versus unexposed)

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13988
R54959		 Magee - Calcium blockers, 1996 Intrauterine death as a whole at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 2.13 [0.89;5.10] C 17/81   9/81 26 81
ref
Total 1 studies 2.13 [0.89;5.10] 26 81
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Magee - Calcium blockers, 1996Magee - Calcium blockers, 1996 2.13[0.89; 5.10]26810%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 Tags Adjustment   - No  - No 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 MatchedMatched 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 All studiesAll studies 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 10.510.01.0

Umbrella review (other published meta-analyses)

Published MATE95% CIn exposedkI2Control groupExposition period AbalosAbalos 0.77[0.28; 2.10]0%-unexposed, sickduring pregnancy (anytime or not specified)studies5 Shekhar (Intravenous labetalol) - GESTATIONAL ...Shekhar (Intravenous labetalol) - GESTATIONAL HYPERTENSION (DUPLICATE) 1.52[0.79; 2.86]NA-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies5 Shekhar (Intravenous labetalol) - GESTATIONAL ...Shekhar (Intravenous labetalol) - GESTATIONAL HYPERTENSION 1.52[0.79; 2.86]NA-exposed to other treatment, sickduring pregnancy (anytime or not specified)studies5 metaPregmetaPreg 2.13[0.89; 5.10]NaN%81--Magee - Calcium blockers, 1996 10.510.01.0