Calcium channel blockers (versus unexposed)

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13988
R54959		 Magee - Calcium blockers, 1996 Intrauterine death as a whole at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 2.13 [0.89;5.10] C 17/81   9/81 26 81
ref
Total 1 studies 2.13 [0.89;5.10] 26 81
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Magee - Calcium blockers, 1996Magee - Calcium blockers, 1996 2.13[0.89; 5.10]26810%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 Tags Adjustment   - No  - No 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 MatchedMatched 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 1 All studiesAll studies 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.13[0.89; 5.10]2681 -NAMagee - Calcium blockers, 1996 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Shekhar (Intravenous labetalol) - GESTATIONAL ...Shekhar (Intravenous labetalol) - GESTATIONAL HYPERTENSION (Intrauterine death) 1.52[0.79; 2.86]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT5 Shekhar (Intravenous labetalol) - GESTATIONAL ...Shekhar (Intravenous labetalol) - GESTATIONAL HYPERTENSION (DUPLICATE) (Intrauterine death) 1.52[0.79; 2.86]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT5 Abalos (Total reported fetal or neonatal deat ...Abalos (Total reported fetal or neonatal death (including miscarriage) (RCT versus no antihypertensive drugs/placebo)) 0.77[0.28; 2.10]0%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT5 metaPregmetaPreg 2.13[0.89; 5.10]NaN%81----Magee - Calcium blockers, 1996 10.510.01.0