Calcium channel blockers (versus unexposed)

Early intrauterine death (< 22 weeks)

id	Study   Auto Weber-Schoendorfer - Calcium blockers, 2008Parazzini - Nifedipine, 1998	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13987 R54921	Weber-Schoendorfer - Calcium blockers, 2008	Miscarriage	at least 1st trimester	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified	2.21 [1.39;3.50]	39/268   59/776	98	268		ref
S13969 R54746	Parazzini - Nifedipine, 1998	Spontaneous abortion (before 20 weeks of gestation)	2nd and/or 3rd trimester	randomized controlled trial	unexposed, sick	Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified	0.19 [0.01;4.05] C	0/132   2/129	2	132		ref
					Total	2 studies	1.06 [0.12;9.51]		100	400
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded