Calcium channel blockers (versus unexposed)

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17153
R71940		 Al Khalaf - Calcium channel blockers (Controls unexposed, disease free), 2022 Stillbirth during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 2.38 [0.76;7.43] C
excluded (control group) 		3/289   7,631/1,739,944 7,634 289
ref
S17150
R71919		 Al Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022 Stillbirth during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 0.30 [0.12;0.74] C 5/1,952   67/7,809 72 1,952
ref
S13987
R54922		 Weber-Schoendorfer - Calcium blockers, 2008 Stillbirths at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.98 [1.02;8.72] 6/268   6/776 12 268
ref
Total 2 studies 0.92 [0.10;8.85] 84 2,220
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Al Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022Al Khalaf - Calcium channel b..., 2022 1 0.30[0.12; 0.74]721,95251%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Weber-Schoendorfer - Calcium blockers, 2008Weber-Schoendorfer - Calcium blockers, 2008 2.98[1.02; 8.72]1226849%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 90% 0.92[0.10; 8.85]842,2200.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.92[0.10; 8.85]842,22090%NAAl Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022 Weber-Schoendorfer - Calcium blockers, 2008 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.98[1.02; 8.71]12268 -NAWeber-Schoendorfer - Calcium blockers, 2008 1 unexposed, sickunexposed, sick 0.30[0.12; 0.74]721,952 -NAAl Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022 1 Tags Adjustment   - No  - No 0.30[0.12; 0.74]721,952 -NAAl Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022 1   - Yes  - Yes 2.98[1.02; 8.71]12268 -NAWeber-Schoendorfer - Calcium blockers, 2008 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 2.98[1.02; 8.71]12268 -NAWeber-Schoendorfer - Calcium blockers, 2008 1   - Only chronic hypertension indication  - Only chronic hypertension indication 0.30[0.12; 0.74]721,952 -NAAl Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022 1 All studiesAll studies 0.92[0.10; 8.85]842,22090%NAAl Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022 Weber-Schoendorfer - Calcium blockers, 2008 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17153

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.68[1.23; 5.85]7,6465570%NAAl Khalaf - Calcium channel blockers (Controls unexposed, disease free), 2022 Weber-Schoendorfer - Calcium blockers, 2008 2 unexposed, sick controlsunexposed, sick controls Out of scale0.30[0.12; 0.74]721,952 -NAAl Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Sridharan (Isradipine) (Stillbirth (versus hy ...Sridharan (Isradipine) (Stillbirth (versus hydralazine)) Out of scale0.10[0.00; 4.60]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 Sridharan (Nifedipine) (Stillbirth (versus hy ...Sridharan (Nifedipine) (Stillbirth (versus hydralazine)) 1.40[0.40; 5.10]NA-Eexposed to other treatment, sickAnyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 0.92[0.10; 8.85]90%2,220----Al Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022 Weber-Schoendorfer - Calcium blockers, 2008 20.510.01.0