Calcium channel blockers (versus unexposed)

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13969
R54740		 Parazzini - Nifedipine, 1998 Induced abortions (for chromosomal fetal malformation) 2nd and/or 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Indications Antihypertensive: All hypertensions, any indications or not specified 0.98 [0.06;15.79] C 1/132   1/129 2 132
ref
S13988
R54957		 Magee - Calcium blockers, 1996 Therapeutic abortions at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 1.22 [0.36;4.16] C 6/81   5/81 11 81
ref
Total 2 studies 1.17 [0.38;3.61] 13 213
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Parazzini - Nifedipine, 1998Parazzini - Nifedipine, 1998 0.98[0.06; 15.79]213216%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Magee - Calcium blockers, 1996Magee - Calcium blockers, 1996 1.22[0.36; 4.16]118184%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.17[0.38; 3.61]132130.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.22[0.36; 4.16]1181 -NAMagee - Calcium blockers, 1996 1 case control studiescase control studies 0 RCTRCT 0.98[0.06; 15.79]2132 -NAParazzini - Nifedipine, 1998 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.22[0.36; 4.16]1181 -NAMagee - Calcium blockers, 1996 1 unexposed, sickunexposed, sick 0.98[0.06; 15.79]2132 -NAParazzini - Nifedipine, 1998 1 Tags Adjustment   - No  - No 1.22[0.36; 4.16]1181 -NAMagee - Calcium blockers, 1996 1   - Randomisation  - Randomisation 0.98[0.06; 15.79]2132 -NAParazzini - Nifedipine, 1998 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 1.17[0.38; 3.61]132130%NAParazzini - Nifedipine, 1998 Magee - Calcium blockers, 1996 2 MatchedMatched 1.22[0.36; 4.16]1181 -NAMagee - Calcium blockers, 1996 1 All studiesAll studies 1.17[0.38; 3.61]132130%NAParazzini - Nifedipine, 1998 Magee - Calcium blockers, 1996 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.22[0.36; 4.16]1181 -NAMagee - Calcium blockers, 1996 1 unexposed, sick controlsunexposed, sick controls 0.98[0.06; 15.79]2132 -NAParazzini - Nifedipine, 1998 10.510.01.0