Calcium channel blockers (versus unexposed) - Medication and Pregnancy KB

Calcium channel blockers (versus unexposed)

Very preterm (28 to 32 weeks)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17153 R71942	Al Khalaf - Calcium channel blockers (Controls unexposed, disease free), 2022	Very preterm birth (less than 32 weeks)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed, disease free excluded	Adjustment: No Indications Antihypertensive: Only chronic hypertension indication	7.19 [4.51;11.46] ^C excluded (control group)	19/279 17,507/1,739,944	17,526	279		ref
S17150 R71921	Al Khalaf - Calcium channel blockers (Controls unexposed, sick), 2022	Very preterm birth (less than 32 weeks)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed, sick	Adjustment: No Indications Antihypertensive: Only chronic hypertension indication	2.67 [1.60;4.44] ^C	17/256 203/7,809	220	256		ref
					Total	1 studies	2.67 [1.60;4.44]		220	256
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17153