Sertraline updated on 07-01-2025

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7468
R22167		 Anderson, 2020 Any neural tube defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.77 [0.45;1.29] -/-   0/- - -
ref
S7352
R21552		 Wemakor, 2015 Neural tube defects 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.92 [0.12;7.02] C 1/15   1,321/18,390 1,322 15
ref
S6244
R16520		 Malm, 2011 Neural tube defects 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.77 [0.43;7.21] -/869   -/628,607 - 869
ref
S6159
R16163		 Louik, 2007 Neural-tube defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.80 [0.10;6.30] 1/47   319/6,133 320 47
ref
Total 4 studies 0.85 [0.54;1.36] 1,642 931
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.77[0.45; 1.29]--79%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Wemakor, 2015Wemakor, 2015 0.92[0.12; 7.02]1,322155%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Malm, 2011Malm, 2011 1.77[0.43; 7.21]-86911%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2007Louik, 2007 0.80[0.10; 6.30]320475%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (4 studies) I2 = 0% 0.85[0.54; 1.36]1,6429310.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.77[0.43; 7.25]-869 -NAMalm, 2011 1 case control studiescase control studies 0.78[0.48; 1.28]1,642620%NAAnderson, 2020 Wemakor, 2015 Louik, 2007 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.85[0.54; 1.36]1,6429310%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 Louik, 2007 4 Tags Adjustment   - No  - No 0.92[0.12; 7.02]1,32215 -NAWemakor, 2015 1   - Yes  - Yes 0.85[0.53; 1.37]3209160%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Monotherapy   - no or not specified  - no or not specified 1.77[0.43; 7.25]-869 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.78[0.47; 1.30]1,322150%NAAnderson, 2020 Wemakor, 2015 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 0.80[0.10; 6.35]32047 -NALouik, 2007 1 All studiesAll studies 0.85[0.54; 1.36]1,6429310%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 Louik, 2007 40.25.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-2.52.31.2680.000Anderson, 2020Wemakor, 2015Malm, 2011Louik, 2007

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.85[0.54; 1.36]1,6429310%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 Louik, 2007 40.510.01.0