Sertraline updated on 07-01-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7468
R22185		 Anderson, 2020 Anorectal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.10 [0.60;2.00] -/-   0/- - -
ref
S6008
R15430		 Furu, 2015 Anal atresia 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.47 [1.09;5.57] 7/7,245   780/2,266,875 787 7,245
ref
S7352
R21533		 Wemakor, 2015 Ano-rectal atresia and stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.50 [0.09;25.25] C 0/14   392/17,461 392 14
ref
S6159
R16164		 Louik, 2007 Anal atresia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 4.40 [1.20;16.40] 3/49   212/6,026 215 49
ref
Total 4 studies 1.89 [0.98;3.64] 1,394 7,308
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.10[0.60; 2.00]--43%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Furu, 2015Furu, 2015 2.47[1.09; 5.57]7877,24533%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.50[0.09; 25.25]392145%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Louik, 2007Louik, 2007 4.40[1.20; 16.40]2154918%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (4 studies) I2 = 38% 1.89[0.98; 3.64]1,3947,3080.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.47[1.09; 5.58]7877,245 -NAFuru, 2015 1 case control studiescase control studies 1.77[0.66; 4.76]6076344%NAAnderson, 2020 Wemakor, 2015 Louik, 2007 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.89[0.98; 3.64]1,3947,30838%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 Louik, 2007 4 Tags Adjustment   - No  - No 1.50[0.09; 25.25]39214 -NAWemakor, 2015 1   - Yes  - Yes 1.98[0.91; 4.30]1,0027,29459%NAAnderson, 2020 Furu, 2015 Louik, 2007 3 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.51[0.85; 2.69]1,1797,25918%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 3   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 4.40[1.19; 16.27]21549 -NALouik, 2007 1 All studiesAll studies 1.89[0.98; 3.64]1,3947,30838%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 Louik, 2007 40.510.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-3.44.01.7270.000Anderson, 2020Furu, 2015Wemakor, 2015Louik, 2007

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.89[0.98; 3.64]1,3947,30838%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 Louik, 2007 40.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Reefhuis (Anal atresia)Reefhuis (Anal atresia) 1.40[0.80; 2.30]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT3 metaPregmetaPreg 1.89[0.98; 3.64]38%7,308----Anderson, 2020 Furu, 2015 Wemakor, 2015 Louik, 2007 40.510.01.0