Sertraline updated on 07-01-2025

Transposition of the great vessels

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7468
R22144		 Anderson, 2020 Transposition of the great arteries 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.12 [0.59;2.15] -/-   0/- - -
ref
S7352
R21540		 Wemakor, 2015 Transposition of great vessels (complete) 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.99 [0.26;15.13] C 1/15   614/17,683 615 15
ref
S6244
R16518		 Malm, 2011 Transposition of the great vessels 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 2.55 [0.35;18.62] 1/869   238/628,607 239 869
ref
Total 3 studies 1.26 [0.70;2.28] 854 884
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.12[0.59; 2.15]--83%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.99[0.26; 15.13]615158%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Malm, 2011Malm, 2011 2.55[0.35; 18.62]2398699%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.26[0.70; 2.28]8548840.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.55[0.35; 18.60]239869 -NAMalm, 2011 1 case control studiescase control studies 1.18[0.64; 2.19]615150%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.26[0.70; 2.28]8548840%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 3 Tags Adjustment   - No  - No 1.99[0.26; 15.13]61515 -NAWemakor, 2015 1   - Yes  - Yes 1.21[0.66; 2.24]2398690%NAAnderson, 2020 Malm, 2011 2 Monotherapy   - no or not specified  - no or not specified 2.55[0.35; 18.60]239869 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.18[0.64; 2.19]615150%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.26[0.70; 2.28]8548840%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.26[0.70; 2.28]8548840%NAAnderson, 2020 Wemakor, 2015 Malm, 2011 30.510.01.0