Sertraline updated on 07-01-2025

Coarctation of aorta

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7468
R22153		 Anderson, 2020 Coarctation of aorta 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.46 [0.20;1.04] -/-   0/- - -
ref
S7352
R21546		 Wemakor, 2015 Coarctation of aorta 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 4.29 [0.97;18.93] C 2/16   568/17,637 570 16
ref
Total 2 studies 1.29 [0.15;11.40] 570 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 0.46[0.20; 1.04]--54%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Wemakor, 2015Wemakor, 2015 4.29[0.97; 18.93]5701646%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 85% 1.29[0.15; 11.40]570160.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.29[0.15; 11.40]5701685%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.29[0.15; 11.40]5701685%NAAnderson, 2020 Wemakor, 2015 2 Tags Adjustment   - No  - No 4.29[0.97; 18.93]57016 -NAWemakor, 2015 1   - Yes  - Yes 0.46[0.20; 1.05]-- -NAAnderson, 2020 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.29[0.15; 11.40]5701685%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.29[0.15; 11.40]5701685%NAAnderson, 2020 Wemakor, 2015 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.29[0.15; 11.40]5701685%NAAnderson, 2020 Wemakor, 2015 20.510.01.0