Sertraline updated on 07-01-2025

Hypoplastic left heart (HLH/HLHS)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7468
R22152		 Anderson, 2020 Hypoplastic left heart syndrome 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.69 [0.92;3.07] -/-   0/- - -
ref
S7352
R21545		 Wemakor, 2015 Hypoplastic left heart 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.48 [0.09;24.87] C 0/14   398/17,467 398 14
ref
Total 2 studies 1.68 [0.93;3.03] 398 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.69[0.92; 3.07]--96%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.48[0.09; 24.87]398144%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.68[0.93; 3.03]398140.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.68[0.93; 3.03]398140%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.68[0.93; 3.03]398140%NAAnderson, 2020 Wemakor, 2015 2 Tags Adjustment   - No  - No 1.48[0.09; 24.87]39814 -NAWemakor, 2015 1   - Yes  - Yes 1.69[0.93; 3.09]-- -NAAnderson, 2020 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.68[0.93; 3.03]398140%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.68[0.93; 3.03]398140%NAAnderson, 2020 Wemakor, 2015 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.68[0.93; 3.03]398140%NAAnderson, 2020 Wemakor, 2015 20.510.01.0