Sertraline updated on 07-01-2025

Low Apgar score (< 7) (at 10 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12953
R49160		 Heinonen, 2021 Low Apgar score (at 10 min) 3rd trimester randomized controlled trial unexposed, sick Adjustment: Randomisation Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.33 [0.01;21.64] C 0/8   0/3 0 8
ref
Total 1 studies 0.33 [0.01;21.64] 0 8
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Heinonen, 2021Heinonen, 2021 0.33[0.01; 21.64]080%ROB confusion: unclearROB selection: lowROB classification: lowROB missing: criticalROB mesure: lowROB reporting: low0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0 RCTRCT 0.33[0.01; 21.64]-8 -NAHeinonen, 2021 1 Type of controls unexposed, sickunexposed, sick 0.33[0.01; 21.64]-8 -NAHeinonen, 2021 1 Tags Adjustment   - Randomisation  - Randomisation 0.33[0.01; 21.64]-8 -NAHeinonen, 2021 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.33[0.01; 21.64]-8 -NAHeinonen, 2021 1 All studiesAll studies 0.33[0.01; 21.64]-8 -NAHeinonen, 2021 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.33[0.01; 21.64]-8 -NAHeinonen, 2021 10.510.01.0