Sertraline updated on 07-01-2025

Persistent pulmonary hypertension

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13130
R50077		 Marks (Controls exposed to Bupropion), 2021 Pulmonary Hypertension during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.72 [0.09;33.38] C 3/1,653   0/406 3 1,653
ref
S6081
R15823		 Kieler, 2012 Persistent pulmonary hypertension of the newborn 2nd and/or 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 2.30 [1.30;4.40] 10/2,843   1,935/1,588,140 1,945 2,843
ref
S5935
R15196		 Chambers, 2006 Persistent pulmonary hypertension of the newborn (PPHN) 2nd and/or 3rd trimester nested case control unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 7.89 [1.63;38.16] C 7/9   370/1,204 377 9
ref
Total 3 studies 2.75 [1.45;5.23] 2,325 4,505
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marks (Controls exposed to Bupropion), 2021Marks, 2021 1 1.72[0.09; 33.38]31,6535%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Kieler, 2012Kieler, 2012 2.30[1.30; 4.40]1,9452,84380%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Chambers, 2006Chambers, 2006 7.89[1.63; 38.16]377916%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 6% 2.75[1.45; 5.23]2,3254,5050.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls exposed to Bupropion;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.27[1.25; 4.13]1,9484,4960%NAMarks (Controls exposed to Bupropion), 2021 Kieler, 2012 2 case control studiescase control studies 7.89[1.63; 38.16]3779 -NAChambers, 2006 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.41[1.11; 10.51]2,3222,85251%NAKieler, 2012 Chambers, 2006 2 exposed to other treatment, sickexposed to other treatment, sick 1.72[0.09; 33.38]31,653 -NAMarks (Controls exposed to Bupropion), 2021 1 Tags Adjustment   - No  - No 5.64[1.40; 22.69]3801,6620%NAMarks (Controls exposed to Bupropion), 2021 Chambers, 2006 2   - Yes  - Yes 2.30[1.25; 4.23]1,9452,843 -NAKieler, 2012 1 MatchedMatched 7.89[1.63; 38.16]3779 -NAChambers, 2006 1 Monotherapy   - no or not specified  - no or not specified 3.41[1.11; 10.51]2,3222,85251%NAKieler, 2012 Chambers, 2006 2   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.72[0.09; 33.38]31,653 -NAMarks (Controls exposed to Bupropion), 2021 1 All studiesAll studies 2.75[1.45; 5.23]2,3254,5056%NAMarks (Controls exposed to Bupropion), 2021 Kieler, 2012 Chambers, 2006 30.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.41[1.11; 10.51]2,3222,85251%NAKieler, 2012 Chambers, 2006 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.72[0.09; 33.38]31,653 -NAMarks (Controls exposed to Bupropion), 2021 10.510.01.0