Sertraline updated on 07-01-2025

Eye, ear, face and neck malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5398
R14841		 Bérard (Controls exposed to non-Sertraline SSRI), 2015 Eye, ear, face, and neck malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.54 [0.07;4.19] C
excluded (control group) 		1/366   10/1,963 11 366
ref
S6705
R18925		 Bérard (Controls unexposed, sick), 2015 Eye, ear, face, and neck malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.46 [0.06;3.32] 1/366   86/14,868 87 366
ref
Total 1 studies 0.46 [0.06;3.42] 87 366
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard (Controls unexposed, sick), 2015Bérard, 2015 1 0.46[0.06; 3.32]873660%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.46[0.06; 3.42]87366 -NABérard (Controls unexposed, sick), 2015 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.46[0.06; 3.42]87366 -NABérard (Controls unexposed, sick), 2015 1 Tags Adjustment   - Yes  - Yes 0.46[0.06; 3.42]87366 -NABérard (Controls unexposed, sick), 2015 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.46[0.06; 3.42]87366 -NABérard (Controls unexposed, sick), 2015 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.46[0.06; 3.42]87366 -NABérard (Controls unexposed, sick), 2015 1 All studiesAll studies 0.46[0.06; 3.42]87366 -NABérard (Controls unexposed, sick), 2015 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5398

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.46[0.06; 3.42]87366 -NABérard (Controls unexposed, sick), 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.54[0.07; 4.19]11366 -NABérard (Controls exposed to non-Sertraline SSRI), 2015 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Shen (Eye, ear, face and neck malformations)Shen (Eye, ear, face and neck malformations) 1.08[0.33; 3.55]32.1%-U,GPunexposed (general population or NOS)T11st trimesterstudies TTT4 metaPregmetaPreg Out of scale0.46[0.06; 3.42]NaN%366----Bérard (Controls unexposed, sick), 2015 10.510.01.0