Sertraline updated on 07-01-2025

Child/Infant death (> 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18438
R78199
Lee (Controls exposed to TCAs), 2025 Infant death (29–365 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.95 [0.02;48.12] C
excluded (control group)
0/643   0/613 0 643
ref
S18420
R77957
Lee (Controls unexposed, general pop), 2025 Infant death (29–365 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.76 [0.17;44.46] C 0/643   130/463,440 130 643
ref
S7927
R23995
Stephansson, 2013 Postneonatal death (death between 28-364 days among neonatal survivors) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.98 [1.07;3.70] C
excluded (exposition period)
10/5,262   1,538/1,604,649 1,548 5,262
ref
S7221
R20595
Colvin, 2012 Death before 1 year during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.45 [0.95;2.22] 22/-   1,058/94,561 1,080 -
ref
Total 2 studies 1.47 [0.97;2.24] 1,210 643
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 2.76[0.17; 44.46]1306432%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Colvin, 2012Colvin, 2012 1.45[0.95; 2.22]1,080-98%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.47[0.97; 2.24]1,2106430.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.47[0.97; 2.24]1,2106430%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.47[0.97; 2.24]1,2106430%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 2 Tags Adjustment   - No  - No 1.47[0.97; 2.24]1,2106430%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 2 Monotherapy   - no or not specified  - no or not specified 1.45[0.95; 2.22]1,080- -NAColvin, 2012 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.76[0.17; 44.46]130643 -NALee (Controls unexposed, general pop), 2025 1 All studiesAll studies 1.47[0.97; 2.24]1,2106430%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18438

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.47[0.97; 2.24]1,2106430%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.95[0.02; 48.12]-643 -NALee (Controls exposed to TCAs), 2025 10.510.01.0