Sertraline updated on 07-01-2025

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7942
R24024		 Sjaarda, 2020 Pregnancy loss (any loss occurring after hCG detection of pregnancy) early pregnancy prospective cohort unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.99 [0.47;2.07] 4/22   143/662 147 22
ref
S7178
R20184		 Colvin, 2011 Terminations of Pregnancy (both spontaneous abortions and elective) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.11 [0.86;1.28] 257/1,167   24,313/119,840 24,570 1,167
ref
Total 2 studies 1.10 [0.91;1.33] 24,717 1,189
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sjaarda, 2020Sjaarda, 2020 0.99[0.47; 2.07]147227%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Colvin, 2011Colvin, 2011 1.11[0.86; 1.28]24,5701,16793%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.10[0.91; 1.33]24,7171,1890.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.10[0.91; 1.33]24,7171,1890%NASjaarda, 2020 Colvin, 2011 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.10[0.91; 1.33]24,7171,1890%NASjaarda, 2020 Colvin, 2011 2 Tags Adjustment   - No  - No 1.11[0.91; 1.35]24,5701,167 -NAColvin, 2011 1   - Yes  - Yes 0.99[0.47; 2.08]14722 -NASjaarda, 2020 1 Monotherapy   - no or not specified  - no or not specified 0.99[0.47; 2.08]14722 -NASjaarda, 2020 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.11[0.91; 1.35]24,5701,167 -NAColvin, 2011 1 All studiesAll studies 1.10[0.91; 1.33]24,7171,1890%NASjaarda, 2020 Colvin, 2011 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.10[0.91; 1.33]24,7171,1890%NASjaarda, 2020 Colvin, 2011 20.510.01.0