Sertraline updated on 07-01-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18438
R78191		 Lee (Controls exposed to TCAs), 2025 Low birth weight (birth weight <2500 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.87 [0.61;1.25] C
excluded (control group) 		63/643   68/613 131 643
ref
S18420
R77949		 Lee (Controls unexposed, general pop), 2025 Low birth weight (birth weight <2500 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.30 [1.00;1.70] 63/643   31,347/463,440 31,410 643
ref
S7699
R22860		 Kivistö, 2016 Low birth weight (<2500 g) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.06 [0.32;3.51] -/49   1,573/24,402 - 49
ref
S7178
R20161		 Colvin, 2011 Birth weight <2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.28 [1.06;1.55] 122/1,361   6,744/94,561 6,866 1,361
ref
Total 3 studies 1.28 [1.10;1.50] 38,276 2,053
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 1.30[1.00; 1.70]31,41064333%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Kivistö, 2016Kivistö, 2016 1.06[0.32; 3.51]-492%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Colvin, 2011Colvin, 2011 1.28[1.06; 1.55]6,8661,36165%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.28[1.10; 1.50]38,2762,0530.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[1.10; 1.50]38,2762,0530%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.28[1.10; 1.50]38,2762,0530%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 3 Tags Adjustment   - No  - No 1.28[1.06; 1.55]6,8661,361 -NAColvin, 2011 1   - Yes  - Yes 1.29[0.99; 1.67]31,4106920%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.29[0.99; 1.67]31,4106920%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.28[1.06; 1.55]6,8661,361 -NAColvin, 2011 1 All studiesAll studies 1.28[1.10; 1.50]38,2762,0530%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18438

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.28[1.10; 1.50]39,8402,0530%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.87[0.61; 1.25]131643 -NALee (Controls exposed to TCAs), 2025 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Vlenterie (Low birth weigh (< 2500 grams))Vlenterie (Low birth weigh (< 2500 grams)) 1.30[0.60; 2.80]-U,GPunexposed (general population or NOS)Anyduring pregnancy (anytime or not specified)studies TTT7 Vlenterie (Low birth weigh (< 2500 grams))Vlenterie (Low birth weigh (< 2500 grams)) 1.20[0.50; 2.70]-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT7 Xing (Low birth weight)Xing (Low birth weight) 1.27[1.05; 1.54]0%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.28[1.10; 1.50]0%2,053----Lee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 30.510.01.0