Antimycotic Azoles (all routes except local only) updated on 01-29-2025

Tetralogy of Fallot

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17739
R74990		 Zhu - Fluconazole, 2020 Tetralogy of Fallot 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 1.19 [0.75;1.90] 18/37,648   751/1,872,961 769 37,648
ref
S17734
R74888		 Howley - Fluconazole, 2016 Tetralogy of Fallot 1st trimester case control unexposed (general population or NOS) Adjustment: No Fluconazole not specified or mixed dose 4.81 [0.78;22.54] 3/9   1,207/12,813 1,210 9
ref
S17735
R74927		 Molgaard-Nielsen - Fluconazole, 2013 Tetralogy of Fallot 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Fluconazole not specified or mixed dose 3.16 [1.49;6.71] 7/7,352   287/968,236 294 7,352
ref
Total 3 studies 2.18 [0.93;5.13] 2,273 45,009
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Zhu - Fluconazole, 2020Zhu - Fluconazole, 2020 1.19[0.75; 1.90]76937,64845%ROB confusion: lowROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Howley - Fluconazole, 2016Howley - Fluconazole, 2016 4.81[0.78; 22.54]1,210917%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Molgaard-Nielsen - Fluconazole, 2013Molgaard-Nielsen - Fluconazole, 2013 3.16[1.49; 6.71]2947,35237%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 68% 2.18[0.93; 5.13]2,27345,0090.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.85[0.71; 4.80]1,06345,00079%NAZhu - Fluconazole, 2020 Molgaard-Nielsen - Fluconazole, 2013 2 case control studiescase control studies 4.81[0.89; 25.86]1,2109 -NAHowley - Fluconazole, 2016 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.18[0.93; 5.13]2,27345,00968%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 Molgaard-Nielsen - Fluconazole, 2013 3 Tags Adjustment   - No  - No 4.81[0.89; 25.86]1,2109 -NAHowley - Fluconazole, 2016 1   - Yes  - Yes 1.85[0.71; 4.80]1,06345,00079%NAZhu - Fluconazole, 2020 Molgaard-Nielsen - Fluconazole, 2013 2 Fluconazole not specified or mixed doseFluconazole not specified or mixed dose 2.18[0.93; 5.13]2,27345,00968%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 Molgaard-Nielsen - Fluconazole, 2013 3 All studiesAll studies 2.18[0.93; 5.13]2,27345,00968%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 Molgaard-Nielsen - Fluconazole, 2013 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.18[0.93; 5.13]2,27345,00968%NAZhu - Fluconazole, 2020 Howley - Fluconazole, 2016 Molgaard-Nielsen - Fluconazole, 2013 30.510.01.0