Clomiphene

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15683
R64803		 Reefhuis, 2011 Cleft lip with or without palate preconceptional for kinetic reason case control unexposed (general population or NOS) Adjustment: Yes Clomiphene exposure: 2 months before conception through the first trimester of pregnancy Clomiphene indications: Not detailled but exclusion of ART including IVF or ICSI 1.10 [0.70;1.80] 26/118   1,672/- 1,698 118
ref
S15714
R64915		 Banhidy, 2008 Cleft lip with/without palate early pregnancy case control unexposed (general population or NOS) Adjustment: Yes Clomiphene exposure: Inadvertently during the first and second months of pregnancy. Clomiphene indications: Inadvertently treated during pregnancy Matched 2.30 [0.60;8.90] 5/101   1,369/39,424 1,374 101
ref
Total 2 studies 1.20 [0.75;1.91] 3,072 219
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reefhuis, 2011Reefhuis, 2011 1.10[0.70; 1.80]1,69811888%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate Banhidy, 2008Banhidy, 2008 2.30[0.60; 8.90]1,37410112%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 2% 1.20[0.75; 1.91]3,0722190.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.20[0.75; 1.91]3,0722192%NAReefhuis, 2011 Banhidy, 2008 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.75; 1.91]3,0722192%NAReefhuis, 2011 Banhidy, 2008 2 Tags Adjustment   - Yes  - Yes 1.20[0.75; 1.91]3,0722192%NAReefhuis, 2011 Banhidy, 2008 2 Clomiphene exposure   - 2 months before conception through ...  - 2 months before conception through the first trimester of pregnancy 1.10[0.69; 1.76]1,698118 -NAReefhuis, 2011 1   - Inadvertently during the first and ...  - Inadvertently during the first and second months of pregnancy. 2.30[0.60; 8.86]1,374101 -NABanhidy, 2008 1 Clomiphene indications   - Inadvertently treated during pregnancy  - Inadvertently treated during pregnancy 2.30[0.60; 8.86]1,374101 -NABanhidy, 2008 1   - Not detailled but exclusion of ART ...  - Not detailled but exclusion of ART including IVF or ICSI 1.10[0.69; 1.76]1,698118 -NAReefhuis, 2011 1 MatchedMatched 2.30[0.60; 8.86]1,374101 -NABanhidy, 2008 1 All studiesAll studies 1.20[0.75; 1.91]3,0722192%NAReefhuis, 2011 Banhidy, 2008 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.75; 1.91]3,0722192%NAReefhuis, 2011 Banhidy, 2008 20.510.01.0