Clomiphene

Atrial septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15683
R64795		 Reefhuis, 2011 Atrial septal defect secundum or NOS preconceptional for kinetic reason case control unexposed (general population or NOS) Adjustment: Yes Clomiphene exposure: 2 months before conception through the first trimester of pregnancy Clomiphene indications: Not detailled but exclusion of ART including IVF or ICSI 1.50 [1.00;2.30] 39/133   1,895/8,301 1,934 133
ref
Total 1 studies 1.50 [0.99;2.27] 1,934 133
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reefhuis, 2011Reefhuis, 2011 1.50[1.00; 2.30]1,9341330%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.50[0.99; 2.27]1,934133 -NAReefhuis, 2011 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.50[0.99; 2.27]1,934133 -NAReefhuis, 2011 1 Tags Adjustment   - Yes  - Yes 1.50[0.99; 2.27]1,934133 -NAReefhuis, 2011 1 Clomiphene exposure   - 2 months before conception through ...  - 2 months before conception through the first trimester of pregnancy 1.50[0.99; 2.27]1,934133 -NAReefhuis, 2011 1 Clomiphene indications   - Not detailled but exclusion of ART ...  - Not detailled but exclusion of ART including IVF or ICSI 1.50[0.99; 2.27]1,934133 -NAReefhuis, 2011 1 All studiesAll studies 1.50[0.99; 2.27]1,934133 -NAReefhuis, 2011 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.50[0.99; 2.27]1,934133 -NAReefhuis, 2011 10.510.01.0