Clomiphene

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15683
R64781		 Reefhuis, 2011 Spina bifida preconceptional for kinetic reason case control unexposed (general population or NOS) Adjustment: Yes Clomiphene exposure: 2 months before conception through the first trimester of pregnancy Clomiphene indications: Not detailled but exclusion of ART including IVF or ICSI 0.80 [0.40;1.80] 9/103   679/7,085 688 103
ref
S15690
R64823		 Wu, 2006 Spinal neural tube defects (spina bifida (ICD9-CM 741), other spinal cord anomalies (ICD9-CM 742.5), or spinocerebellar disease (ICD9-CM 334)) preconceptional for kinetic reason nested case control unexposed (general population or NOS) Adjustment: No Clomiphene exposure: 2 months before conception through the first month of pregnancy Clomiphene indications: Not detailled but exclusion of in vitro fertilization (IVF) treatments 11.70 [2.00;44.80] 3/35   15/1,591 18 35
ref
Total 2 studies 2.80 [0.20;38.54] 706 138
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reefhuis, 2011Reefhuis, 2011 0.80[0.40; 1.80]68810353%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate Wu, 2006Wu, 2006 11.70[2.00; 44.80]183547%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 89% 2.80[0.20; 38.54]7061380.250.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.80[0.20; 38.54]70613889%NAReefhuis, 2011 Wu, 2006 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.80[0.20; 38.54]70613889%NAReefhuis, 2011 Wu, 2006 2 Tags Adjustment   - No  - No 11.70[2.47; 55.37]1835 -NAWu, 2006 1   - Yes  - Yes 0.80[0.38; 1.70]688103 -NAReefhuis, 2011 1 Clomiphene exposure   - 2 months before conception through ...  - 2 months before conception through the first month of pregnancy 11.70[2.47; 55.37]1835 -NAWu, 2006 1   - 2 months before conception through ...  - 2 months before conception through the first trimester of pregnancy 0.80[0.38; 1.70]688103 -NAReefhuis, 2011 1 Clomiphene indications   - Not detailled but exclusion of ART ...  - Not detailled but exclusion of ART including IVF or ICSI 0.80[0.38; 1.70]688103 -NAReefhuis, 2011 1   - Not detailled but exclusion of in v ...  - Not detailled but exclusion of in vitro fertilization (IVF) treatments 11.70[2.47; 55.37]1835 -NAWu, 2006 1 All studiesAll studies 2.80[0.20; 38.54]70613889%NAReefhuis, 2011 Wu, 2006 20.250.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.80[0.20; 38.54]70613889%NAReefhuis, 2011 Wu, 2006 20.510.01.0