Clomiphene

Choanal atresia

id	Study   Auto Reefhuis, 2011	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15683 R64802	Reefhuis, 2011	Choanal atresia	preconceptional for kinetic reason	case control	unexposed (general population or NOS)	Adjustment: Yes Clomiphene exposure: 2 months before conception through the first trimester of pregnancy Clomiphene indications: Not detailled but exclusion of ART including IVF or ICSI	2.70 [0.90;7.80]	4/98   78/6,484	82	98		ref
					Total	1 studies	2.70 [0.92;7.95]		82	98
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded