Clomiphene

Polydactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15714
R64920		 Banhidy, 2008 Poly/syndactyly early pregnancy case control unexposed (general population or NOS) Adjustment: No Clomiphene exposure: Inadvertently during the first and second months of pregnancy. Clomiphene indications: Inadvertently treated during pregnancy Matched 0.46 [0.11;1.85] C 2/98   1,742/39,797 1,744 98
ref
Total 1 studies 0.46 [0.11;1.85] 1,744 98
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Banhidy, 2008Banhidy, 2008 0.46[0.11; 1.85]1,744980%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.46[0.11; 1.85]1,74498 -NABanhidy, 2008 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.46[0.11; 1.85]1,74498 -NABanhidy, 2008 1 Tags Adjustment   - No  - No 0.46[0.11; 1.85]1,74498 -NABanhidy, 2008 1 Clomiphene exposure   - Inadvertently during the first and ...  - Inadvertently during the first and second months of pregnancy. 0.46[0.11; 1.85]1,74498 -NABanhidy, 2008 1 Clomiphene indications   - Inadvertently treated during pregnancy  - Inadvertently treated during pregnancy 0.46[0.11; 1.85]1,74498 -NABanhidy, 2008 1 MatchedMatched 0.46[0.11; 1.85]1,74498 -NABanhidy, 2008 1 All studiesAll studies 0.46[0.11; 1.85]1,74498 -NABanhidy, 2008 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.46[0.11; 1.85]1,74498 -NABanhidy, 2008 10.510.01.0