Clomiphene - Medication and Pregnancy KB

Clomiphene

Major congenital malformations

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15758 R65134	Nehard, 2024	Major congenital malformations (exclusion of chromosomal abnormalities or genetic defects)	1st trimester	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes Clomiphene exposure: Inadvertently during the first trimester of pregnancy (< 12 SA). Clomiphene indications: Inadvertently treated during pregnancy Matched	0.79 [0.23;2.74]	3/262 19/1,062	22	262		ref
S15680 R64745	Weller, 2017	All major malformations	preconceptional for kinetic reason	retrospective cohort	unexposed (general population or NOS)	Adjustment: Yes Clomiphene exposure: 2 months before conception through the first month of pregnancy Clomiphene indications: Not detailled but exclusion of in vitro fertilization (IVF) treatments	1.12 [0.91;1.38]	126/1,861 5,962/98,728	6,088	1,861		ref
S15714 R64913	Banhidy, 2008	Congenital abnormality	early pregnancy	case control	unexposed (general population or NOS)	Adjustment: No Clomiphene exposure: Inadvertently during the first and second months of pregnancy. Clomiphene indications: Inadvertently treated during pregnancy Matched	1.17 [0.85;1.59] ^C	67/163 22,776/60,831	22,843	163		ref
					Total	3 studies	1.13 [0.95;1.34]		28,953	2,286
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded