Clomiphene

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15680
R64746		 Weller, 2017 Malformation of central nervous system (ICD-9 codes 740–743) preconceptional for kinetic reason retrospective cohort unexposed (general population or NOS) Adjustment: Yes Clomiphene exposure: 2 months before conception through the first month of pregnancy Clomiphene indications: Not detailled but exclusion of in vitro fertilization (IVF) treatments 0.92 [0.51;1.66] 17/1,861   822/98,728 839 1,861
ref
Total 1 studies 0.92 [0.51;1.66] 839 1,861
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Weller, 2017Weller, 2017 0.92[0.51; 1.66]8391,8610%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: critical0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.92[0.51; 1.66]8391,861 -NAWeller, 2017 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.92[0.51; 1.66]8391,861 -NAWeller, 2017 1 Tags Adjustment   - Yes  - Yes 0.92[0.51; 1.66]8391,861 -NAWeller, 2017 1 Clomiphene exposure   - 2 months before conception through ...  - 2 months before conception through the first month of pregnancy 0.92[0.51; 1.66]8391,861 -NAWeller, 2017 1 Clomiphene indications   - Not detailled but exclusion of in v ...  - Not detailled but exclusion of in vitro fertilization (IVF) treatments 0.92[0.51; 1.66]8391,861 -NAWeller, 2017 1 All studiesAll studies 0.92[0.51; 1.66]8391,861 -NAWeller, 2017 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.92[0.51; 1.66]8391,861 -NAWeller, 2017 10.510.01.0