Clomiphene

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15758
R67009		 Nehard, 2024 Miscarriage (abortion of a foetus before 22 weeks of amenorrhea or a weight of less than 500 g) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Clomiphene exposure: Inadvertently during the first trimester of pregnancy (< 12 SA). Clomiphene indications: Inadvertently treated during pregnancy Matched 1.82 [1.16;2.85] C 30/309   69/1,236 99 309
ref
Total 1 studies 1.82 [1.16;2.85] 99 309
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nehard, 2024Nehard, 2024 1.82[1.16; 2.85]993090%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: moderateROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.82[1.16; 2.85]99309 -NANehard, 2024 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.82[1.16; 2.85]99309 -NANehard, 2024 1 Tags Adjustment   - No  - No 1.82[1.16; 2.85]99309 -NANehard, 2024 1 Clomiphene exposure   - Inadvertently during the first trim ...  - Inadvertently during the first trimester of pregnancy (< 12 SA). 1.82[1.16; 2.85]99309 -NANehard, 2024 1 Clomiphene indications   - Inadvertently treated during pregnancy  - Inadvertently treated during pregnancy 1.82[1.16; 2.85]99309 -NANehard, 2024 1 MatchedMatched 1.82[1.16; 2.85]99309 -NANehard, 2024 1 All studiesAll studies 1.82[1.16; 2.85]99309 -NANehard, 2024 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.82[1.16; 2.85]99309 -NANehard, 2024 10.510.01.0