Clomiphene

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15758
R67023		 Nehard, 2024 Preterm birth (< 37 weeks gestational age) 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Clomiphene exposure: Inadvertently during the first trimester of pregnancy (< 12 SA). Clomiphene indications: Inadvertently treated during pregnancy Matched 1.62 [1.03;2.54] C 29/241   78/999 107 241
ref
S15744
R65142		 Malchau, 2014 Preterm birth (gestational age <37 weeks) preconceptional for kinetic reason population based cohort retrospective unexposed, sick Adjustment: Yes Clomiphene exposure: 1 month before pregnancy Clomiphene indications: Ovarian stimulation for infertility (NOS) 1.04 [0.71;1.54] -/1,357   -/1,744 - 1,357
ref
Total 2 studies 1.28 [0.83;1.96] 107 1,598
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nehard, 2024Nehard, 2024 1.62[1.03; 2.54]10724146%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: criticalROB mesure: moderateROB reporting: moderate Malchau, 2014Malchau, 2014 1.04[0.71; 1.54]-1,35754%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 52% 1.28[0.83; 1.96]1071,5980.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[0.83; 1.96]1071,59852%NANehard, 2024 Malchau, 2014 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.62[1.03; 2.54]107241 -NANehard, 2024 1 unexposed, sickunexposed, sick 1.04[0.71; 1.54]-1,357 -NAMalchau, 2014 1 Tags Adjustment   - No  - No 1.62[1.03; 2.54]107241 -NANehard, 2024 1   - Yes  - Yes 1.04[0.71; 1.54]-1,357 -NAMalchau, 2014 1 Clomiphene exposure   - 1 month before pregnancy  - 1 month before pregnancy 1.04[0.71; 1.54]-1,357 -NAMalchau, 2014 1   - Inadvertently during the first trim ...  - Inadvertently during the first trimester of pregnancy (< 12 SA). 1.62[1.03; 2.54]107241 -NANehard, 2024 1 Clomiphene indications   - Inadvertently treated during pregnancy  - Inadvertently treated during pregnancy 1.62[1.03; 2.54]107241 -NANehard, 2024 1   - Ovarian stimulation for infertility ...  - Ovarian stimulation for infertility (NOS) 1.04[0.71; 1.54]-1,357 -NAMalchau, 2014 1 MatchedMatched 1.62[1.03; 2.54]107241 -NANehard, 2024 1 All studiesAll studies 1.28[0.83; 1.96]1071,59852%NANehard, 2024 Malchau, 2014 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.62[1.03; 2.54]107241 -NANehard, 2024 1 unexposed, sick controlsunexposed, sick controls 1.04[0.71; 1.54]-1,357 -NAMalchau, 2014 10.510.01.0