Clomiphene

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15758
R67021		 Nehard, 2024 Birth weight < 2500g 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Clomiphene exposure: Inadvertently during the first trimester of pregnancy (< 12 SA). Clomiphene indications: Inadvertently treated during pregnancy Matched 1.38 [0.84;2.29] C 22/236   68/984 90 236
ref
S15744
R65141		 Malchau, 2014 Low birth weight (LBW, birth weight <2,500 grams) preconceptional for kinetic reason population based cohort retrospective unexposed, sick Adjustment: Yes Clomiphene exposure: 1 month before pregnancy Clomiphene indications: Ovarian stimulation for infertility (NOS) 1.46 [1.03;2.06] -/1,357   -/1,744 - 1,357
ref
Total 2 studies 1.43 [1.08;1.91] 90 1,593
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nehard, 2024Nehard, 2024 1.38[0.84; 2.29]9023632%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: criticalROB mesure: moderateROB reporting: moderate Malchau, 2014Malchau, 2014 1.46[1.03; 2.06]-1,35768%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.43[1.08; 1.91]901,5930.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.43[1.08; 1.91]901,5930%NANehard, 2024 Malchau, 2014 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.38[0.84; 2.29]90236 -NANehard, 2024 1 unexposed, sickunexposed, sick 1.46[1.03; 2.06]-1,357 -NAMalchau, 2014 1 Tags Adjustment   - No  - No 1.38[0.84; 2.29]90236 -NANehard, 2024 1   - Yes  - Yes 1.46[1.03; 2.06]-1,357 -NAMalchau, 2014 1 Clomiphene exposure   - 1 month before pregnancy  - 1 month before pregnancy 1.46[1.03; 2.06]-1,357 -NAMalchau, 2014 1   - Inadvertently during the first trim ...  - Inadvertently during the first trimester of pregnancy (< 12 SA). 1.38[0.84; 2.29]90236 -NANehard, 2024 1 Clomiphene indications   - Inadvertently treated during pregnancy  - Inadvertently treated during pregnancy 1.38[0.84; 2.29]90236 -NANehard, 2024 1   - Ovarian stimulation for infertility ...  - Ovarian stimulation for infertility (NOS) 1.46[1.03; 2.06]-1,357 -NAMalchau, 2014 1 MatchedMatched 1.38[0.84; 2.29]90236 -NANehard, 2024 1 All studiesAll studies 1.43[1.08; 1.91]901,5930%NANehard, 2024 Malchau, 2014 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.38[0.84; 2.29]90236 -NANehard, 2024 1 unexposed, sick controlsunexposed, sick controls 1.46[1.03; 2.06]-1,357 -NAMalchau, 2014 10.510.01.0