Clomiphene

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15724
R65139		 Gorgui, 2022 Small for gestational age (< 10th percentile for birth weight according to gestational age and sex using Canadian population-based references) preconceptional for kinetic reason retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Clomiphene exposure: 2 months before conception through the first month of pregnancy Clomiphene indications: Any or not specified 1.22 [0.86;1.73] 34/302   5,364/55,569 5,398 302
ref
S15744
R65143		 Malchau, 2014 Small for gestational age (birth weight <10th percentile taking into account child gender, and standard intrauterine growth curves) preconceptional for kinetic reason population based cohort retrospective unexposed, sick Adjustment: Yes Clomiphene exposure: 1 month before pregnancy Clomiphene indications: Ovarian stimulation for infertility (NOS) 1.62 [1.11;2.38] -/1,357   -/1,744 - 1,357
ref
Total 2 studies 1.39 [1.05;1.83] 5,398 1,659
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Gorgui, 2022Gorgui, 2022 1.22[0.86; 1.73]5,39830254%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Malchau, 2014Malchau, 2014 1.62[1.11; 2.38]-1,35746%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 12% 1.39[1.05; 1.83]5,3981,6590.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.39[1.05; 1.83]5,3981,65912%NAGorgui, 2022 Malchau, 2014 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.22[0.86; 1.73]5,398302 -NAGorgui, 2022 1 unexposed, sickunexposed, sick 1.62[1.10; 2.37]-1,357 -NAMalchau, 2014 1 Tags Adjustment   - Yes  - Yes 1.39[1.05; 1.83]5,3981,65912%NAGorgui, 2022 Malchau, 2014 2 Clomiphene exposure   - 1 month before pregnancy  - 1 month before pregnancy 1.62[1.10; 2.37]-1,357 -NAMalchau, 2014 1   - 2 months before conception through ...  - 2 months before conception through the first month of pregnancy 1.22[0.86; 1.73]5,398302 -NAGorgui, 2022 1 Clomiphene indications   - Any or not specified  - Any or not specified 1.22[0.86; 1.73]5,398302 -NAGorgui, 2022 1   - Ovarian stimulation for infertility ...  - Ovarian stimulation for infertility (NOS) 1.62[1.10; 2.37]-1,357 -NAMalchau, 2014 1 All studiesAll studies 1.39[1.05; 1.83]5,3981,65912%NAGorgui, 2022 Malchau, 2014 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.22[0.86; 1.73]5,398302 -NAGorgui, 2022 1 unexposed, sick controlsunexposed, sick controls 1.62[1.10; 2.37]-1,357 -NAMalchau, 2014 10.510.01.0