Proton Pump Inhibitors updated on 08-09-2023

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4444
R10535		 Cluver - Esomeprazole, 2018 Neonatal intensive care unit admission late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation 2.20 [0.62;7.73] C 8/59   4/60 12 59
ref
S4515
R11142		 Saleh, 2017 Admission to NICU (neonatal intensive care unit) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Matched 1.22 [0.57;2.62] C 19/40   34/80 53 40
ref
Total 2 studies 1.43 [0.75;2.75] 65 99
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cluver - Esomeprazole, 2018Cluver - Esomeprazole, 2018 2.20[0.62; 7.73]125927%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Saleh, 2017Saleh, 2017 1.22[0.57; 2.62]534073%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.43[0.75; 2.75]65990.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.22[0.57; 2.62]5340 -NASaleh, 2017 1 case control studiescase control studies 0 RCTRCT 2.20[0.62; 7.73]1259 -NACluver - Esomeprazole, 2018 1 Type of controls unexposed, sickunexposed, sick 1.43[0.75; 2.75]65990%NACluver - Esomeprazole, 2018 Saleh, 2017 2 Tags Adjustment   - No  - No 1.22[0.57; 2.62]5340 -NASaleh, 2017 1   - Randomisation  - Randomisation 2.20[0.62; 7.73]1259 -NACluver - Esomeprazole, 2018 1 MatchedMatched 1.22[0.57; 2.62]5340 -NASaleh, 2017 1 All studiesAll studies 1.43[0.75; 2.75]65990%NACluver - Esomeprazole, 2018 Saleh, 2017 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.43[0.75; 2.75]65990%NACluver - Esomeprazole, 2018 Saleh, 2017 20.510.01.0