Proton Pump Inhibitors updated on 08-09-2023

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14451
R57331		 Breddels, 2022 Gestational diabetes mellitus (GDM) (any degree of glucose intolerance with the onset during pregnancy) 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.20 [1.00;1.45] -/-   -/- - -
ref
Total 1 studies 1.20 [1.00;1.44] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Breddels, 2022Breddels, 2022 1.20[1.00; 1.45]--0%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.20[1.00; 1.44]-- -NABreddels, 2022 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[1.00; 1.44]-- -NABreddels, 2022 1 Tags Adjustment   - Yes  - Yes 1.20[1.00; 1.44]-- -NABreddels, 2022 1 All studiesAll studies 1.20[1.00; 1.44]-- -NABreddels, 2022 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[1.00; 1.44]-- -NABreddels, 2022 10.510.01.0