Proton Pump Inhibitors updated on 08-09-2023

Postpartum hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4444
R10520		 Cluver - Esomeprazole, 2018 Major postpartum hemorrhage (> 1000 mL) late pregnancy randomized controlled trial unexposed, sick Adjustment: Randomisation 0.14 [0.01;2.73] C 0/59   3/60 3 59
ref
S4515
R11141		 Saleh, 2017 Post-partum hemorrhage during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Matched 0.73 [0.18;2.91] C 3/40   8/80 11 40
ref
Total 2 studies 0.54 [0.15;1.91] 14 99
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cluver - Esomeprazole, 2018Cluver - Esomeprazole, 2018 0.14[0.01; 2.73]35918%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Saleh, 2017Saleh, 2017 0.73[0.18; 2.91]114082%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.54[0.15; 1.91]14990.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.73[0.18; 2.91]1140 -NASaleh, 2017 1 case control studiescase control studies 0 RCTRCT 0.14[0.01; 2.73]359 -NACluver - Esomeprazole, 2018 1 Type of controls unexposed, sickunexposed, sick 0.54[0.15; 1.91]14990%NACluver - Esomeprazole, 2018 Saleh, 2017 2 Tags Adjustment   - No  - No 0.73[0.18; 2.91]1140 -NASaleh, 2017 1   - Randomisation  - Randomisation 0.14[0.01; 2.73]359 -NACluver - Esomeprazole, 2018 1 MatchedMatched 0.73[0.18; 2.91]1140 -NASaleh, 2017 1 All studiesAll studies 0.54[0.15; 1.91]14990%NACluver - Esomeprazole, 2018 Saleh, 2017 20.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.54[0.15; 1.91]14990%NACluver - Esomeprazole, 2018 Saleh, 2017 20.510.01.0