Proton Pump Inhibitors updated on 08-09-2023

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4275
R10700		 Pasternak, 2010 Cleft lip with or without cleft palate 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.30 [0.07;1.23] 2/3,651   -/- - 3,651
ref
S4861
R12550		 Ruigomez - Omeprazole (Controls exposed to other treatment, sick), 1999 Cleft lip with cleft palate 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.36 [0.06;33.59] C
excluded (control group) 		0/139   1/567 1 139
ref
S4276
R9959		 Ruigomez - Omeprazole (Controls unexposed NOS), 1999 Cleft lip with cleft palate 1st trimester retrospective cohort unexposed (general population or NOS) Adjustment: No 3.79 [0.15;93.41] C 0/139   1/1,575 1 139
ref
Total 2 studies 0.70 [0.07;7.28] 1 3,790
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pasternak, 2010Pasternak, 2010 0.30[0.07; 1.23]-3,65167%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Ruigomez - Omeprazole (Controls unexposed NOS), 1999Ruigomez - Omeprazole, 1999 1 3.79[0.15; 93.41]113933%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 50% 0.70[0.07; 7.28]13,7900.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.70[0.07; 7.28]13,79050%NAPasternak, 2010 Ruigomez - Omeprazole (Controls unexposed NOS), 1999 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.70[0.07; 7.28]13,79050%NAPasternak, 2010 Ruigomez - Omeprazole (Controls unexposed NOS), 1999 2 Tags Adjustment   - No  - No 3.79[0.15; 93.41]1139 -NARuigomez - Omeprazole (Controls unexposed NOS), 1999 1   - Yes  - Yes 0.30[0.07; 1.26]-3,651 -NAPasternak, 2010 1 All studiesAll studies 0.70[0.07; 7.28]13,79050%NAPasternak, 2010 Ruigomez - Omeprazole (Controls unexposed NOS), 1999 20.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4861

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.70[0.07; 7.28]13,79050%NAPasternak, 2010 Ruigomez - Omeprazole (Controls unexposed NOS), 1999 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.36[0.06; 33.59]1139 -NARuigomez - Omeprazole (Controls exposed to other treatment, sick), 1999 10.510.01.0