Proton Pump Inhibitors updated on 08-09-2023

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4446
R10564		 Matok, 2012 Ventricular septal defect 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.93 [0.55;1.58] 14/1,159   1,171/108,385 1,185 1,159
ref
S4275
R10698		 Pasternak, 2010 Ventricular septal defect 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.20 [0.73;1.97] 18/3,651   -/- - 3,651
ref
S4431
R10744		 Källèn, 1998 Ventricular septum defect 1st trimester population based cohort retrospective exposed to other treatment, sick Adjustment: No 4.91 [0.25;95.64] C 3/275   0/191 3 275
ref
Total 3 studies 1.09 [0.76;1.56] 1,188 5,085
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Matok, 2012Matok, 2012 0.93[0.55; 1.58]1,1851,15946%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Pasternak, 2010Pasternak, 2010 1.20[0.73; 1.97]-3,65152%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Källèn, 1998Källèn, 1998 4.91[0.25; 95.64]32751%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.09[0.76; 1.56]1,1885,0850.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.09[0.76; 1.56]1,1885,0850%NAMatok, 2012 Pasternak, 2010 Källèn, 1998 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.06[0.74; 1.53]1,1854,8100%NAMatok, 2012 Pasternak, 2010 2 exposed to other treatment, sickexposed to other treatment, sick 4.91[0.25; 95.64]3275 -NAKällèn, 1998 1 Tags Adjustment   - No  - No 4.91[0.25; 95.64]3275 -NAKällèn, 1998 1   - Yes  - Yes 1.06[0.74; 1.53]1,1854,8100%NAMatok, 2012 Pasternak, 2010 2 All studiesAll studies 1.09[0.76; 1.56]1,1885,0850%NAMatok, 2012 Pasternak, 2010 Källèn, 1998 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.06[0.74; 1.53]1,1944,8100%NAMatok, 2012 Pasternak, 2010 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.91[0.25; 95.64]3275 -NAKällèn, 1998 10.510.01.0