Proton Pump Inhibitors updated on 08-09-2023

Atrial septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4446
R10565		 Matok, 2012 Atrial septal defect 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.44 [0.88;2.34] 17/1,159   745/108,385 762 1,159
ref
S4275
R10699		 Pasternak, 2010 Atrial septal defect 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.11 [0.67;1.85] 17/3,651   -/- - 3,651
ref
S4431
R10745		 Källèn, 1998 Atrium septum defect 1st trimester population based cohort retrospective exposed to other treatment, sick Adjustment: No 2.09 [0.08;51.57] C 1/275   0/191 1 275
ref
Total 3 studies 1.28 [0.90;1.81] 763 5,085
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Matok, 2012Matok, 2012 1.44[0.88; 2.34]7621,15951%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Pasternak, 2010Pasternak, 2010 1.11[0.67; 1.85]-3,65148%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Källèn, 1998Källèn, 1998 2.09[0.08; 51.57]12751%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.28[0.90; 1.81]7635,0850.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.28[0.90; 1.81]7635,0850%NAMatok, 2012 Pasternak, 2010 Källèn, 1998 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.27[0.89; 1.81]7624,8100%NAMatok, 2012 Pasternak, 2010 2 exposed to other treatment, sickexposed to other treatment, sick 2.09[0.08; 51.57]1275 -NAKällèn, 1998 1 Tags Adjustment   - No  - No 2.09[0.08; 51.57]1275 -NAKällèn, 1998 1   - Yes  - Yes 1.27[0.89; 1.81]7624,8100%NAMatok, 2012 Pasternak, 2010 2 All studiesAll studies 1.28[0.90; 1.81]7635,0850%NAMatok, 2012 Pasternak, 2010 Källèn, 1998 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.27[0.89; 1.81]7704,8100%NAMatok, 2012 Pasternak, 2010 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.09[0.08; 51.57]1275 -NAKällèn, 1998 10.510.01.0