Proton Pump Inhibitors updated on 08-09-2023

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4293
R10502		 Lalkin - Omeprazole (Controls exposed to other treatment, sick), 1998 Cesarean section during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched 1.06 [0.52;2.18] C
excluded (control group) 		18/91   19/101 37 91
ref
S4407
R10501		 Lalkin - Omeprazole (Controls unexposed NOS), 1998 Cesarean section during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched 0.97 [0.48;1.98] C 18/91   20/99 38 91
ref
Total 1 studies 0.97 [0.48;1.98] 38 91
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lalkin - Omeprazole (Controls unexposed NOS), 1998Lalkin - Omeprazole, 1998 1 0.97[0.48; 1.98]38910%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.97[0.48; 1.98]3891 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.97[0.48; 1.98]3891 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 Tags Adjustment   - No  - No 0.97[0.48; 1.98]3891 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 MatchedMatched 0.97[0.48; 1.98]3891 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 All studiesAll studies 0.97[0.48; 1.98]3891 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4293

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.97[0.48; 1.98]3891 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.06[0.52; 2.18]3791 -NALalkin - Omeprazole (Controls exposed to other treatment, sick), 1998 10.510.01.0