Proton Pump Inhibitors updated on 08-08-2023

Patent ductus arterious

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18821
R80088		 Segal, 2024 Patent ductus arteriosus (PDA) in term newborns (diagnosed by echocardiography [ICD-9] diagnosis code 747.0) 1st trimester case control unexposed (general population or NOS) Adjustment: No Matched 3.50 [2.26;5.44] C 38/81   1,846/9,164 1,884 81
ref
S4431
R10746		 Källèn, 1998 Patent ductus arteriosus 1st trimester population based cohort retrospective exposed to other treatment, sick Adjustment: No 2.09 [0.08;51.57] C 1/275   0/191 1 275
ref
Total 2 studies 3.47 [2.25;5.36] 1,885 356
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Segal, 2024Segal, 2024 3.50[2.26; 5.44]1,8848198%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate Källèn, 1998Källèn, 1998 2.09[0.08; 51.57]12752%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 3.47[2.25; 5.36]1,8853560.910.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.09[0.08; 51.57]1275 -NAKällèn, 1998 1 case control studiescase control studies 3.50[2.26; 5.44]1,88481 -NASegal, 2024 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.50[2.26; 5.44]1,88481 -NASegal, 2024 1 exposed to other treatment, sickexposed to other treatment, sick 2.09[0.08; 51.57]1275 -NAKällèn, 1998 1 Tags Adjustment   - No  - No 3.47[2.25; 5.36]1,8853560%NASegal, 2024 Källèn, 1998 2 MatchedMatched 3.50[2.26; 5.44]1,88481 -NASegal, 2024 1 All studiesAll studies 3.47[2.25; 5.36]1,8853560%NASegal, 2024 Källèn, 1998 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.50[2.26; 5.44]1,88481 -NASegal, 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.09[0.08; 51.57]1275 -NAKällèn, 1998 10.510.01.0