Proton Pump Inhibitors - Medication and Pregnancy KB

Proton Pump Inhibitors updated on 08-09-2023

Down syndrom / Trisomy 21

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S4861 R12591	Ruigomez - Omeprazole (Controls exposed to other treatment, sick), 1999	Down's syndrom	1st trimester	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.36 [0.06;33.59] ^C excluded (control group)	0/139 1/567	1	139		ref
S4276 R12491	Ruigomez - Omeprazole (Controls unexposed NOS), 1999	Down's syndrom	1st trimester	retrospective cohort	unexposed (general population or NOS)	Adjustment: No	11.37 [0.22;575.17] ^C	0/139 0/1,575	0	139		ref
S4431 R10754	Källèn, 1998	Down's syndrome	1st trimester	population based cohort retrospective	exposed to other treatment, sick	Adjustment: No	2.09 [0.08;51.57] ^C	1/275 0/191	1	275		ref
					Total	2 studies	4.12 [0.34;49.29]		1	414
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed NOS;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4861