Proton Pump Inhibitors updated on 08-09-2023

Hydrocephaly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14453
R57354		 Choi a, 2023 Hydrocephalus 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 0.94 [0.54;1.63] 13/40,540   784/2,655,676 797 40,540
ref
S4818
R12390		 Munch, 2014 Isolated congenital hydrocephalus 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 2.35 [1.26;4.41] 10/7,762   465/844,721 475 7,762
ref
Total 2 studies 1.47 [0.60;3.60] 1,272 48,302
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Choi a, 2023Choi a, 2023 0.94[0.54; 1.63]79740,54051%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: NAROB reporting: NA Munch, 2014Munch, 2014 2.35[1.26; 4.41]4757,76249%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 78% 1.47[0.60; 3.60]1,27248,3020.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.94[0.54; 1.63]79740,540 -NAChoi a, 2023 1 case control studiescase control studies 2.35[1.26; 4.40]4757,762 -NAMunch, 2014 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.35[1.26; 4.40]4757,762 -NAMunch, 2014 1 unexposed, sickunexposed, sick 0.94[0.54; 1.63]79740,540 -NAChoi a, 2023 1 Tags Adjustment   - Yes  - Yes 1.47[0.60; 3.60]1,27248,30278%NAChoi a, 2023 Munch, 2014 2 All studiesAll studies 1.47[0.60; 3.60]1,27248,30278%NAChoi a, 2023 Munch, 2014 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.35[1.26; 4.40]4757,762 -NAMunch, 2014 1 unexposed, sick controlsunexposed, sick controls 0.94[0.54; 1.63]79740,540 -NAChoi a, 2023 10.510.01.0