Proton Pump Inhibitors updated on 08-09-2023

Hypoplastic left heart (HLH/HLHS)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4446
R10570		 Matok, 2012 Hypoplastic left heart syndrome 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 2.99 [0.39;22.66] 1/1,159   19/108,385 20 1,159
ref
Total 1 studies 2.99 [0.39;22.79] 20 1,159
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Matok, 2012Matok, 2012 2.99[0.39; 22.66]201,1590%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.99[0.39; 22.79]201,159 -NAMatok, 2012 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.99[0.39; 22.79]201,159 -NAMatok, 2012 1 Tags Adjustment   - Yes  - Yes 2.99[0.39; 22.79]201,159 -NAMatok, 2012 1 All studiesAll studies 2.99[0.39; 22.79]201,159 -NAMatok, 2012 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.99[0.39; 22.79]201,159 -NAMatok, 2012 10.510.01.0