Proton Pump Inhibitors updated on 08-08-2023

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14451
R57337		 Breddels, 2022 Apgar score 5 min after birth (AS5min) < 7 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.84 [0.66;1.06] -/-   -/- - -
ref
S4446
R10578		 Matok, 2012 Apgar 5 min ≤ 7 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.50 [0.19;1.35] 4/-   1,056/- 1,060 -
ref
S4459
R10586		 Källén - Omeprazole, 2001 Low Apgar score (< 7 at 5 min) at least 1st trimester excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No 0.61 [0.23;1.62]
excluded (exposition period) 		-/-   -/- - -
ref
Total 2 studies 0.81 [0.64;1.04] 1,060 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Breddels, 2022Breddels, 2022 0.84[0.66; 1.06]--94%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Matok, 2012Matok, 2012 0.50[0.19; 1.35]1,060-6%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 2% 0.81[0.64; 1.04]1,060-0.22.01.0ROB: A: confounding, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.81[0.64; 1.04]1,060-2%NABreddels, 2022 Matok, 2012 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.81[0.64; 1.04]1,060-2%NABreddels, 2022 Matok, 2012 2 Tags Adjustment   - Yes  - Yes 0.81[0.64; 1.04]1,060-2%NABreddels, 2022 Matok, 2012 2 All studiesAll studies 0.81[0.64; 1.04]1,060-2%NABreddels, 2022 Matok, 2012 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.81[0.64; 1.04]1,060-2%NABreddels, 2022 Matok, 2012 20.510.01.0