Proton Pump Inhibitors updated on 08-09-2023

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4446
R10574		 Matok, 2012 Perinatal mortality 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.32 [0.08;1.31] 2/666   1,348/108,878 1,350 666
ref
S4459
R10582		 Källén - Omeprazole, 2001 Perinatally dead at least 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.66 [0.70;3.98] 5/863   -/- - 863
ref
Total 2 studies 0.80 [0.16;3.98] 1,350 1,529
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Matok, 2012Matok, 2012 0.32[0.08; 1.31]1,35066644%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Källén - Omeprazole, 2001Källén - Omeprazole, 2001 1.66[0.70; 3.98]-86356%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 74% 0.80[0.16; 3.98]1,3501,5290.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.16; 3.98]1,3501,52974%NAMatok, 2012 Källén - Omeprazole, 2001 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.16; 3.98]1,3501,52974%NAMatok, 2012 Källén - Omeprazole, 2001 2 Tags Adjustment   - No  - No 1.66[0.70; 3.96]-863 -NAKällén - Omeprazole, 2001 1   - Yes  - Yes 0.32[0.08; 1.29]1,350666 -NAMatok, 2012 1 All studiesAll studies 0.80[0.16; 3.98]1,3501,52974%NAMatok, 2012 Källén - Omeprazole, 2001 20.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.16; 3.98]1,3501,52974%NAMatok, 2012 Källén - Omeprazole, 2001 20.510.01.0