Proton Pump Inhibitors updated on 08-09-2023

Bone fractures / bone mineralisation anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8890
R29991		 Wolfe (Controls exposed to other treatment, sick), 2019 Early childhood fracture (ICD-9: 810-829) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.30 [0.73;2.33] C
excluded (control group) 		92/10,547   13/1,932 105 10,547
ref
S8889
R29990		 Wolfe (Controls unexposed NOS), 2019 Early childhood fracture (ICD-9: 810-829) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.73 [0.59;0.89] 92/10,547   4,380/365,671 4,472 10,547
ref
Total 1 studies 0.73 [0.59;0.90] 4,472 10,547
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wolfe (Controls unexposed NOS), 2019Wolfe, 2019 1 0.73[0.59; 0.89]4,47210,5470%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.73[0.59; 0.90]4,47210,547 -NAWolfe (Controls unexposed NOS), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.73[0.59; 0.90]4,47210,547 -NAWolfe (Controls unexposed NOS), 2019 1 Tags Adjustment   - Yes  - Yes 0.73[0.59; 0.90]4,47210,547 -NAWolfe (Controls unexposed NOS), 2019 1 All studiesAll studies 0.73[0.59; 0.90]4,47210,547 -NAWolfe (Controls unexposed NOS), 2019 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8890

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.73[0.59; 0.90]4,47210,547 -NAWolfe (Controls unexposed NOS), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.30[0.73; 2.33]10510,547 -NAWolfe (Controls exposed to other treatment, sick), 2019 10.510.01.0