Proton Pump Inhibitors updated on 08-09-2023

Infant allergies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14452
R57346		 Noh, 2023 Any allergic disease during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Matched 1.00 [0.98;1.01] -/36,529   -/146,116 - 36,529
ref
S4417
R10453		 Mulder, 2014 Allergic disease during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.25 [0.98;1.59] 85/319   8,456/33,047 8,541 319
ref
S4492
R10773		 Dehlink (Controls exposed to other treatment, sick), 2009 Infant allergy during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.07 [0.85;1.36] C
excluded (control group) 		220/2,916   114/1,613 334 2,916
ref
S4421
R10462		 Dehlink (Controls unexposed NOS), 2009 Infant allergy during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.46 [1.27;1.66] 220/2,916   29,270/582,800 29,490 2,916
ref
Total 3 studies 1.21 [0.91;1.61] 38,031 39,764
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Noh, 2023Noh, 2023 1.00[0.98; 1.01]-36,52937%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Mulder, 2014Mulder, 2014 1.25[0.98; 1.59]8,54131929%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Dehlink (Controls unexposed NOS), 2009Dehlink, 2009 1 1.46[1.27; 1.66]29,4902,91634%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 94% 1.21[0.91; 1.61]38,03139,7640.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.21[0.91; 1.61]38,03139,76494%NANoh, 2023 Mulder, 2014 Dehlink (Controls unexposed NOS), 2009 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.40[1.22; 1.60]38,0313,23517%NAMulder, 2014 Dehlink (Controls unexposed NOS), 2009 2 unexposed, sickunexposed, sick 1.00[0.99; 1.02]-36,529 -NANoh, 2023 1 Tags Adjustment   - Yes  - Yes 1.40[1.22; 1.60]38,0313,23517%NAMulder, 2014 Dehlink (Controls unexposed NOS), 2009 2 MatchedMatched 1.00[0.99; 1.02]-36,529 -NANoh, 2023 1 All studiesAll studies 1.21[0.91; 1.61]38,03139,76494%NANoh, 2023 Mulder, 2014 Dehlink (Controls unexposed NOS), 2009 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4492

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.40[1.22; 1.60]38,0313,23517%NAMulder, 2014 Dehlink (Controls unexposed NOS), 2009 2 unexposed, sick controlsunexposed, sick controls 1.00[0.99; 1.02]-36,529 -NANoh, 2023 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.07[0.85; 1.36]3342,916 -NADehlink (Controls exposed to other treatment, sick), 2009 10.510.01.0