Proton Pump Inhibitors updated on 08-09-2023

Oro-facial clefts

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14453
R57361		 Choi a, 2023 Oral clefts 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes 0.94 [0.70;1.28] 49/40,540   3,220/2,655,676 3,269 40,540
ref
Total 1 studies 0.94 [0.70;1.27] 3,269 40,540
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Choi a, 2023Choi a, 2023 0.94[0.70; 1.28]3,26940,5400%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.94[0.70; 1.27]3,26940,540 -NAChoi a, 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.94[0.70; 1.27]3,26940,540 -NAChoi a, 2023 1 Tags Adjustment   - Yes  - Yes 0.94[0.70; 1.27]3,26940,540 -NAChoi a, 2023 1 All studiesAll studies 0.94[0.70; 1.27]3,26940,540 -NAChoi a, 2023 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.94[0.70; 1.27]3,26940,540 -NAChoi a, 2023 10.510.01.0