Proton Pump Inhibitors updated on 08-09-2023

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4675
R11475		 Andersen (Controls exposed to clarithromycin), 2013 Miscarriage 1st trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: Yes 0.59 [0.42;0.84]
excluded (control group) 		-/3,577   -/401 - 3,577
ref
S4493
R10797		 Andersen (Controls unexposed, NOS), 2013 Miscarriage 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 1.03 [0.91;1.18] -/3,577   -/927,927 - 3,577
ref
Total 1 studies 1.03 [0.90;1.17] 0 3,577
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (Controls unexposed, NOS), 2013Andersen, 2013 1 1.03[0.91; 1.18]-3,5770%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.90; 1.17]-3,577 -NAAndersen (Controls unexposed, NOS), 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.90; 1.17]-3,577 -NAAndersen (Controls unexposed, NOS), 2013 1 Tags Adjustment   - Yes  - Yes 1.03[0.90; 1.17]-3,577 -NAAndersen (Controls unexposed, NOS), 2013 1 All studiesAll studies 1.03[0.90; 1.17]-3,577 -NAAndersen (Controls unexposed, NOS), 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4675

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.90; 1.17]-3,577 -NAAndersen (Controls unexposed, NOS), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.59[0.42; 0.83]-3,577 -NAAndersen (Controls exposed to clarithromycin), 2013 10.510.01.0