Proton Pump Inhibitors updated on 08-09-2023

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4293
R10738		 Lalkin - Omeprazole (Controls exposed to other treatment, sick), 1998 Therapeutic abortion during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched 2.06 [0.50;8.43] C
excluded (control group) 		6/113   3/113 9 113
ref
S4407
R10740		 Lalkin - Omeprazole (Controls unexposed NOS), 1998 Therapeutic abortion during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Matched 1.21 [0.36;4.09] C 6/113   5/113 11 113
ref
Total 1 studies 1.21 [0.36;4.09] 11 113
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lalkin - Omeprazole (Controls unexposed NOS), 1998Lalkin - Omeprazole, 1998 1 1.21[0.36; 4.09]111130%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.21[0.36; 4.09]11113 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.21[0.36; 4.09]11113 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 Tags Adjustment   - No  - No 1.21[0.36; 4.09]11113 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 MatchedMatched 1.21[0.36; 4.09]11113 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 All studiesAll studies 1.21[0.36; 4.09]11113 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 4293

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.21[0.36; 4.09]11113 -NALalkin - Omeprazole (Controls unexposed NOS), 1998 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.06[0.50; 8.43]9113 -NALalkin - Omeprazole (Controls exposed to other treatment, sick), 1998 10.510.01.0