Proton Pump Inhibitors updated on 08-09-2023

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S4515
R10904		 Saleh, 2017 Prematurity (< 34 weeks) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Matched 0.59 [0.25;1.37] C 10/40   29/80 39 40
ref
S4359
R10429		 Nielsen, 1999 Preterm (< 34 weeks) (Exposure at any time) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.03 [0.14;7.51] C 1/51   253/13,327 254 51
ref
Total 2 studies 0.64 [0.29;1.40] 293 91
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Saleh, 2017Saleh, 2017 0.59[0.25; 1.37]394085%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Nielsen, 1999Nielsen, 1999 1.03[0.14; 7.51]2545115%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.64[0.29; 1.40]293910.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.64[0.29; 1.40]293910%NASaleh, 2017 Nielsen, 1999 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.03[0.14; 7.51]25451 -NANielsen, 1999 1 unexposed, sickunexposed, sick 0.59[0.25; 1.37]3940 -NASaleh, 2017 1 Tags Adjustment   - No  - No 0.64[0.29; 1.40]293910%NASaleh, 2017 Nielsen, 1999 2 MatchedMatched 0.59[0.25; 1.37]3940 -NASaleh, 2017 1 All studiesAll studies 0.64[0.29; 1.40]293910%NASaleh, 2017 Nielsen, 1999 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.14; 7.51]25451 -NANielsen, 1999 1 unexposed, sick controlsunexposed, sick controls 0.59[0.25; 1.37]3940 -NASaleh, 2017 10.510.01.0